Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

EFG_C Elongation factor G C-terminus

SMART accession number:	SM00838
Description:	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.
Interpro abstract (IPR000640):	Elongation factor 2 (EF2 or EFG) is folded into five domains, with domains I and II forming the N-terminal block, domains IV and V forming the C-terminal block, and domain III providing the covalently-linked flexible connection between the two [ (PUBMED:11054294) ]. This entry represents the domain V of EF2 of both prokaryotes and eukaryotes (also known as eEF2). This domain is also found in elongation factor 4 and some tetracycline resistance proteins and adopts a ferredoxin-like fold [ (PUBMED:12471894) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 76176 EFG_C domains in 76171 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing EFG_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with EFG_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing EFG_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: translation
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 33.33 map00450 Selenoamino acid metabolism 33.33 map00230 Purine metabolism 33.33 map00920 Sulfur metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EFG_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing EFG_C domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of EFG_C domains in PDB

  PDB code	Main view	Title
  1dar		ELONGATION FACTOR G IN COMPLEX WITH GDP
  1efg		THE CRYSTAL STRUCTURE OF ELONGATION FACTOR G COMPLEXED WITH GDP, AT 2.7 ANGSTROMS RESOLUTION
  1elo		ELONGATION FACTOR G WITHOUT NUCLEOTIDE
  1fnm		STRUCTURE OF THERMUS THERMOPHILUS EF-G H573A
  1jqm		Fitting of L11 protein and elongation factor G (EF-G) in the cryo-em map of e. coli 70S ribosome bound with EF-G, GDP and fusidic acid
  1jqs		Fitting of L11 protein and elongation factor G (domain G' and V) in the cryo-em map of E. coli 70S ribosome bound with EF-G and GMPPCP, a nonhydrolysable GTP analog
  1ktv		Crystal Structure of Elongation Factor G Dimer Without Nucleotide
  1n0u		Crystal structure of yeast elongation factor 2 in complex with sordarin
  1n0v		Crystal structure of elongation factor 2
  1pn6		Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low resolution map of the release complex.Puromycin.EFG.GDPNP of E.coli 70S ribosome.
  1u2r		Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
  1wdt		Crystal structure of ttk003000868 from Thermus thermophilus HB8
  1zm2		Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA
  1zm3		Structure of the apo eEF2-ETA complex
  1zm4		Structure of the eEF2-ETA-bTAD complex
  1zm9		Structure of eEF2-ETA in complex with PJ34
  1zn0		Coordinates of RRF and EF-G fitted into Cryo-EM map of the 50S subunit bound with both EF-G (GDPNP) and RRF
  2bm0		Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A
  2bm1		Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A.
  2bv3		Crystal structure of a mutant elongation factor G trapped with a GTP analogue
  2dy1		Crystal structure of EF-G-2 from Thermus thermophilus
  2e1r		Structure of eEF2 in complex with a sordarin derivative
  2efg		TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP
  2j7k		Crystal structure of the T84A mutant EF-G:GDPCP complex
  2mzw		2MZW
  2npf		Structure of eEF2 in complex with moriniafungin
  2om7		Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors
  2p8w		Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction
  2p8x		Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP cryo-EM reconstruction
  2p8y		Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDP:sordarin cryo-EM reconstruction
  2p8z		Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP:sordarin cryo-EM reconstruction
  2rdo		50S subunit with EF-G(GDPNP) and RRF bound
  2xex		crystal structure of Staphylococcus aureus elongation factor G
  2ywe		Crystal structure of LepA from Aquifex aeolicus
  2ywf		Crystal structure of GMPPNP-bound LepA from Aquifex aeolicus
  2ywg		Crystal structure of GTP-bound LepA from Aquifex aeolicus
  2ywh		Crystal structure of GDP-bound LepA from Aquifex aeolicus
  2zit		Structure of the eEF2-ExoA-NAD+ complex
  3b78		Structure of the eEF2-ExoA(R551H)-NAD+ complex
  3b82		Structure of the eEF2-ExoA(E546H)-NAD+ complex
  3b8h		Structure of the eEF2-ExoA(E546A)-NAD+ complex
  3cb4		The Crystal Structure of LepA
  3deg		Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP
  3dny		Fitting of the eEF2 crystal structure into the cryo-EM density map of the eEF2.80S.AlF4-.GDP complex
  3e3x		The C-terminal part of BipA protein from Vibrio parahaemolyticus RIMD 2210633
  3izp		Conformation of EF-G during translocation
  3j0e		Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex
  3j25		Structural basis for TetM-mediated tetracycline resistance
  3j7p		3J7P
  3j9y		3J9Y
  3j9z		3J9Z
  3ja1		3JA1
  3jb9		3JB9
  3jcd		3JCD
  3jce		3JCE
  3jcm		3JCM
  3jcr		3JCR
  3zz0		Crystal structure of ribosomal elongation factor (EF)-G from Staphylococcus aureus with a fusidic acid hyper-sensitivity mutation M16I
  3zzt		Crystal structure of Staphylococcus aureus elongation factor G with a fusidic-acid-resistant mutation F88L
  3zzu		Crystal structure of Staphylococcus aureus elongation factor G with mutations M16I and F88L
  4fn5		ELONGATION FACTOR G 1 (PSEUDOMONAS AERUGINOSA) IN COMPLEX WITH Argyrin B
  4m1k		4M1K
  4myt		4MYT
  4myu		4MYU
  4v4b		4V4B
  4v5f		4V5F
  4v5m		4V5M
  4v5n		4V5N
  4v6t		4V6T
  4v6v		4V6V
  4v6w		4V6W
  4v6x		4V6X
  4v7b		4V7B
  4v7d		4V7D
  4v8u		4V8U
  4v90		4V90
  4v9h		4V9H
  4v9j		4V9J
  4v9k		4V9K
  4v9l		4V9L
  4v9m		4V9M
  4v9o		4V9O
  4v9p		4V9P
  4w29		4W29
  4w2e		4W2E
  4wpo		4WPO
  4wqf		4WQF
  4wqu		4WQU
  4wqy		4WQY
  4zci		4ZCI
  4zck		4ZCK
  4zcl		4ZCL
  4zcm		4ZCM
  5a9v		5A9V
  5a9w		5A9W
  5a9x		5A9X
  5a9y		5A9Y
  5a9z		5A9Z
  5aa0		5AA0
  5anb		5ANB
  5anc		5ANC
  5gam		5GAM
  5gan		5GAN
  5gm6		5GM6
  5gmk		5GMK
  5hau		5HAU
  5imq		5IMQ
  5imr		5IMR
  5it7		5IT7
  5j8b		5J8B
  5juo		5JUO
  5jup		5JUP
  5jus		5JUS
  5jut		5JUT
  5juu		5JUU
  5kcs		5KCS
  5lj3		5LJ3
  5lj5		5LJ5
  5lqw		5LQW

• Links (links to other resources describing this domain)

• PFAM	EFG_C
  INTERPRO	IPR000640

Send comments to Ivica Letunic