Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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EKR Domain of unknown function

SMART accession number:	SM00890
Description:	EKR is a short, 33 residue, domain found in bacterial and some lower eukaryotic species which lies between a POR (pyruvate ferredoxin/flavodoxin oxidoreductase) and the 4Fe-4S binding domain Fer4. It contains a characteristic EKR sequence motif. The exact function of this domain is not known.
Interpro abstract (IPR019456):	EKR is a short, 33 residue, domain found in bacterial and some lower eukaryotic species which lies between a POR (pyruvate ferredoxin/flavodoxin oxidoreductase) domain ( IPR019752 ) and the 4Fe-4S binding domain ( IPR017896 ). It contains a characteristic EKR sequence motif. The exact function of this domain is not known.
GO process:	oxidation-reduction process (GO:0055114)
GO function:	oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 4864 EKR domains in 4864 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing EKR domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with EKR domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing EKR domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of EKR domains in PDB

  PDB code	Main view	Title
  1b0p		CRYSTAL STRUCTURE OF PYRUVATE-FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS
  1kek		Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase
  2c3m		Crystal Structure Of Pyruvate-Ferredoxin Oxidoreductase From Desulfovibrio africanus
  2c3o		CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM Desulfovibrio africanus
  2c3p		CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM Desulfovibrio africanus
  2c3u		Crystal Structure Of Pyruvate-Ferredoxin Oxidoreductase From Desulfovibrio africanus, Oxygen inhibited form
  2c3y		CRYSTAL STRUCTURE OF THE RADICAL FORM OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM Desulfovibrio africanus
  2c42		Crystal Structure Of Pyruvate-Ferredoxin Oxidoreductase From Desulfovibrio africanus
  2pda		CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN PYRUVATE-FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS AND PYRUVATE.
  2uza		CRYSTAL STRUCTURE OF THE FREE RADICAL INTERMEDIATE OF PYRUVATE:FERREDOXIN OXIDOREDUCTASE FROM DESULFOVIBRIO AFRICANUS

• Links (links to other resources describing this domain)

• PFAM	EKR
  INTERPRO	IPR019456

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