The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.
The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [ (PUBMED:17855421) ].
Family alignment:
There are 6818 FIST domains in 6814 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing FIST domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FIST domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing FIST domain in the selected taxonomic class.
FIST: a sensory domain for diverse signal transduction pathways inprokaryotes and ubiquitin signaling in eukaryotes.
Bioinformatics. 2007; 23: 2518-21
Display abstract
MOTIVATION: Sensory domains that are conserved among Bacteria, Archaea andEucarya are important detectors of common signals detected by livingcells. Due to their high sequence divergence, sensory domains aredifficult to identify. We systematically look for novel sensory domainsusing sensitive profile-based searches initiated with regions of signaltransduction proteins where no known domains can be identified by currentdomain models. RESULTS: Using profile searches followed by multiplesequence alignment, structure prediction and domain architecture analysis,we have identified a novel sensory domain termed FIST, which is present insignal transduction proteins from Bacteria, Archaea and Eucarya.Chromosomal proximity of FIST-encoding genes to those coding for proteinsinvolved in amino acid metabolism and transport suggest that FIST domainsbind small ligands, such as amino acids.
Links (links to other resources describing this domain)
