The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids. PMID:17855421
This entry represents a novel sensory domain, designated FIST_C (short for F-box and intracellular signal transduction, C-terminal), which is present in signal transduction proteins from bacteria, archaea and eukaryotes. The chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [ (PUBMED:17855421) ].
Family alignment:
There are 7371 FIST_C domains in 7366 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing FIST_C domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FIST_C domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing FIST_C domain in the selected taxonomic class.
FIST: a sensory domain for diverse signal transduction pathways in prokaryotesand ubiquitin signaling in eukaryotes.
Bioinformatics. 2007; 23: 2518-21
Display abstract
MOTIVATION: Sensory domains that are conserved among Bacteria, Archaea andEucarya are important detectors of common signals detected by living cells. Dueto their high sequence divergence, sensory domains are difficult to identify. We systematically look for novel sensory domains using sensitive profile-basedsearches initiated with regions of signal transduction proteins where no knowndomains can be identified by current domain models. RESULTS: Using profilesearches followed by multiple sequence alignment, structure prediction and domainarchitecture analysis, we have identified a novel sensory domain termed FIST,which is present in signal transduction proteins from Bacteria, Archaea andEucarya. Chromosomal proximity of FIST-encoding genes to those coding forproteins involved in amino acid metabolism and transport suggest that FISTdomains bind small ligands, such as amino acids.
Links (links to other resources describing this domain)
