Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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FMN_bind

SMART accession number:	SM00900
Description:	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.
Interpro abstract (IPR007329):	This conserved region includes the FMN-binding site of the NqrC protein [ (PUBMED:11248234) ] as well as the NosR and NirI regulatory proteins.
GO component:	membrane (GO:0016020)
GO function:	FMN binding (GO:0010181)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 21830 FMN_bind domains in 20063 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing FMN_bind domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FMN_bind domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing FMN_bind domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: interaction
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Barquera B, Hase CC, Gennis RB
  • Expression and mutagenesis of the NqrC subunit of the NQR respiratoryNa(+) pump from Vibrio cholerae with covalently attached FMN.
  • FEBS Lett. 2001; 492: 45-9
  • Display abstract

  • The Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR) is presentin the membranes of a number of marine bacteria and pathogenic bacteria.Two of the six subunits of the Na(+)-NQR, NqrB and NqrC, have beenpreviously shown to contain covalently bound flavin adenine mononucleotide(FMN). In the current work, the cloning of nqrC from Vibrio cholerae isreported. The gene has been expressed in V. cholerae and shown to containone equivalent of covalently bound FMN. In contrast, no covalent flavinwas detected when threonine-225 was replaced by leucine. The data showthat the FMN attachment does not require assembly of the enzyme and areconsistent with the unusual threonine attachment site.

• Structure (3D structures containing this domain)

• 3D Structures of FMN_bind domains in PDB

  PDB code	Main view	Title
  2kzx		Solution NMR Structure of A3DHT5 from Clostridium thermocellum, Northeast Structural Genomics Consortium Target CmR116
  3dcz		CRYSTAL STRUCTURE OF A PUTATIVE RNFG SUBUNIT OF ELECTRON TRANSPORT COMPLEX (TM0246) FROM THERMOTOGA MARITIMA AT 1.65 A RESOLUTION
  3lwx		Crystal structure of Na(+)-translocating NADH-quinone reductase subunit C (YP_001302508.1) from Parabacteroides distasonis ATCC 8503 at 1.10 A resolution
  3o6u		Crystal Structure of CPE2226 protein from Clostridium perfringens. Northeast Structural Genomics Consortium Target CpR195
  4p6v		4P6V
  4u9s		4U9S
  4xa7		4XA7
  4xhf		4XHF

• Links (links to other resources describing this domain)

• PFAM	FMN_bind
  INTERPRO	IPR007329

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