Formiminotransferase domain
SMART accession number:SM01221
Description: Formiminotransferase domain.
Interpro abstract (IPR013802):

The formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD) forms a homodimer, with each protomer being comprised of two subdomains. The formiminotransferase domain has an N-terminal subdomain that is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [ (PUBMED:10673422) ]. In humans, deficiency of this enzyme results in a disease phenotype [ (PUBMED:12815595) ].

This entry represents the C-terminal subdomain of the formiminotransferase domain.

GO function:folic acid binding (GO:0005542), transferase activity (GO:0016740)
Family alignment:
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There are 2848 FTCD domains in 2847 proteins in SMART's nrdb database.

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