Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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G3P_acyltransf Glycerol-3-phosphate acyltransferase

SMART accession number:	SM01207
Description:	This family of enzymes catalyses the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid. PMID: 16949372
Interpro abstract (IPR003811):	PlsY is a glycerol-3-phosphate acyltransferase (GPAT) ( EC 2.3.1.n3 ) that catalyses the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid (LPA) [ (PUBMED:16949372) ]. During this process, PlsY utilises a novel acyl-donor, acyl-phosphate produced by PlsX. In some bacteria, the PlsX/Y system plays a major part at the initial stage of glycerolipid synthesis [ (PUBMED:17308305) (PUBMED:19282621) ]. However, in E. coli, the other GPAT, PlsB (described in IPR028354 ) is also involved in this process [ (PUBMED:19282621) ].
GO process:	phospholipid biosynthetic process (GO:0008654)
GO component:	plasma membrane (GO:0005886)
GO function:	acyl-phosphate glycerol-3-phosphate acyltransferase activity (GO:0043772)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 15602 G3P_acyltransf domains in 15602 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing G3P_acyltransf domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with G3P_acyltransf domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing G3P_acyltransf domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Lu YJ, Zhang YM, Grimes KD, Qi J, Lee RE, Rock CO
  • Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positivepathogens.
  • Mol Cell. 2006; 23: 765-72
  • Display abstract

  • It is not known how Gram-positive bacterial pathogens carry outglycerol-3-phosphate (G3P) acylation, which is the first step in the formation ofphosphatidic acid, the key intermediate in membrane phospholipid synthesis. InEscherichia coli, acylation of the 1-position of G3P is carried out by PlsB;however, the majority of bacteria lack a plsB gene and in others it is notessential. We describe a two-step pathway that utilizes a new fatty acidintermediate for the initiation of phospholipid formation. First, PlsX produces aunique activated fatty acid by catalyzing the synthesis of fatty acyl-phosphatefrom acyl-acyl carrier protein, and then PlsY transfers the fatty acid fromacyl-phosphate to the 1-position of G3P. The PlsX/Y pathway defines the mostwidely distributed pathway for the initiation of phospholipid formation inbacteria and represents a new target for the development of antibacterialtherapeutics.

• Links (links to other resources describing this domain)

• INTERPRO	IPR003811
  PFAM	G3P_acyltransf

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