HAP1 N-terminal conserved region
SMART accession number:SM01424
Description: This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntingtons disease is unclear PMID:7477378,9599014,9285789. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34 PMID:11161814.
Family alignment:
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There are 0 HAP1_N domains in 0 proteins in SMART's nrdb database.

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