Helix-turn-helix diphteria tox regulatory element
SMART accession number:SM00529
Description: iron dependent repressor
Interpro abstract (IPR022689):

The diphtheria toxin repressor protein (DTXR) is a member of this group [ (PUBMED:7568230) ]. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [ (PUBMED:7743135) ].

This entry represents a group of iron dependent repressors, including MntR, IdeR and diphtheria toxin repressor.

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:transition metal ion binding (GO:0046914), DNA-binding transcription factor activity (GO:0003700)
Family alignment:
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There are 14037 HTH_DTXR domains in 14034 proteins in SMART's nrdb database.

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