helix_turn_helix isocitrate lyase regulation
SMART accession number:SM00346
Description: -
Interpro abstract (IPR005471):

The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One of these subfamilies, called 'iclR', groups several proteins including:

  • gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces.
  • iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium.

These proteins have a Helix-Turn-Helix motif at the N terminus that is similar to that of other DNA-binding proteins [ (PUBMED:1840643) ].

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 58065 HTH_ICLR domains in 57593 proteins in SMART's nrdb database.

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