This family consists of hypothetical membrane protein insertion efficiency factor proteins. They contain three conserved cysteine residues. They may be involved in insertion of integral membrane proteins into the membrane [ (PUBMED:21803992) ].
Family alignment:
There are 17740 Haemolytic domains in 17739 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing Haemolytic domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Haemolytic domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing Haemolytic domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Characterization of a hemolysin gene ytjA from Bacillus subtilis.
Curr Microbiol. 2009; 58: 642-7
Display abstract
Bacillus subtilis is popularly used as a probiotic in many fields. Althoughrecent research has found that some secondary metabolites of B. subtilis couldcause hemolysis, the hemolytic mechanism in B. subtilis is still unclear. In thispaper, the hemolysis-associated gene ytjA was cloned and expressed in Escherichiacoli, and the hemolytic activity of the expressed soluble protein was indicatedby the presence of clear hemolytic zones on sheep blood agar plates. In addition,reverse transcriptase-polymerase chain reaction analysis confirmed that the ytjA gene was transcribed in B. subtilis. These results suggest that ytjA is one ofthe hemolysin genes responsible for hemolysis in B. subtilis.
Links (links to other resources describing this domain)
