SMART accession number:SM01252
Description: Conserved DNA-binding domain that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses.
Interpro abstract (IPR018004):

The amino-terminal module of the poxvirus D6R/NIR proteins defines a novel conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses [ (PUBMED:11897024) ]. Putative proteins with homology to the KilA-N domain have also been identified in Maverick transposable elements of the parabasalid protozoa Trichomonas vaginalis [ (PUBMED:17034960) ]. The KilA-N domain has been suggested to be homologous to the fungal DNA-binding APSES domain. In all proteins shown to contain the KilA-N domain, it occurs at the extreme amino terminus accompanied by a wide range of distinct carboxy-terminal domains. These carboxy-terminal modules may be enzymes, such as the nuclease domains, or might mediate additional, specific interactions with nucleic acids or proteins, like the RING or CCCH fingers in the poxviruses [ (PUBMED:11897024) ]. The KilA-N domain is predicted to adopt an alpha-beta fold with four conserved strands and at least two conserved helices [ (PUBMED:11897024) ]. Some proteins known to contain a KilA-N domain are listed below:

  • Bacteriophage P1 protein kilA ( P19653 ).
  • Fowlpox virus (FPV) protein FPV236 ( P14365 ).
  • Trichomonas vaginalis G3 Putative uncharacterised protein ( A2D8C0 ).
  • Vaccinia virus hypothetical 21.7kDa HindIII-C protein ( P17366 ).

Family alignment:
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There are 6304 KilA-N domains in 6296 proteins in SMART's nrdb database.

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