SMART accession number:SM00505
Description: Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins.
Interpro abstract (IPR003614):

Knottins are small proteins characterised by a cystine-knot [ (PUBMED:18025039) ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [ (PUBMED:15551519) ].

The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [ (PUBMED:8380707) ] and the scorpion alpha-neurotoxins [ (PUBMED:12925796) ]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I.

GO process:defense response (GO:0006952)
Family alignment:
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There are 3746 Knot1 domains in 3435 proteins in SMART's nrdb database.

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