Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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LYZ2 Lysozyme subfamily 2

SMART accession number:	SM00047
Description:	Eubacterial enzymes distantly related to eukaryotic lysozymes.
Interpro abstract (IPR002901):	This domain is found in many different proteins including mannosyl-glycoprotein endo-beta-N-acetylglucosamidase ( EC 3.2.1.96 ). It is also found in flagellar protein J ( P75942 ), which has been shown to hydrolyse peptidoglycan [ (PUBMED:10049388) ].
GO function:	amidase activity (GO:0004040)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 3116 LYZ2 domains in 3113 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing LYZ2 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LYZ2 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing LYZ2 domain in the selected taxonomic class.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 30.00 map00511 N-Glycan degradation 30.00 map01032 Glycan structures - degradation 20.00 map02040 Flagellar assembly 6.67 map00550 Peptidoglycan biosynthesis 3.33 map00604 Glycosphingolipid biosynthesis - ganglioseries 3.33 map00531 Glycosaminoglycan degradation 3.33 map00530 Aminosugars metabolism 3.33 map00603 Glycosphingolipid biosynthesis - globoseries This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LYZ2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing LYZ2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of LYZ2 domains in PDB

  PDB code	Main view	Title
  2zyc		Crystal structure of peptidoglycan hydrolase from Sphingomonas sp. A1
  3fi7		Crystal Structure of the autolysin Auto (Lmo1076) from Listeria monocytogenes, catalytic domain
  3k3t		E185A mutant of peptidoglycan hydrolase from Sphingomonas sp. A1
  3vwo		Crystal structure of peptidoglycan hydrolase mutant from Sphingomonas sp. A1
  4kt3		Structure of a type VI secretion system effector-immunity complex from Pseudomonas protegens
  4pi7		4PI7
  4pi8		4PI8
  4pi9		4PI9
  4pia		4PIA
  4q2w		4Q2W
  4qdn		4QDN
  5azm		5AZM
  5dn4		5DN4
  5dn5		5DN5

• Links (links to other resources describing this domain)

• INTERPRO	IPR002901

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