Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Leuk-A4-hydro_C Leukotriene A4 hydrolase, C-terminal

SMART accession number:	SM01263
Description:	Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase (PUBMED:11175901).
Interpro abstract (IPR015211):	This C-terminal domain is found in peptidases belonging to MEROPS peptidase family M1, particularly: aminopeptidase-1 of Caenorhabditis elegans, aminopeptidase O, aminopeptidase B and the bifunctional leukotriene A4 (LTA-4) hydrolase/aminopeptidase. The domain adopts a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. It is required for the formation of a deep cleft harbouring the catalytic Zn2+ site in leukotriene A4 hydrolase [ (PUBMED:11175901) ].
GO function:	zinc ion binding (GO:0008270), metallopeptidase activity (GO:0008237)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 3901 Leuk-A4-hydro_C domains in 3898 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Leuk-A4-hydro_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Leuk-A4-hydro_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Leuk-A4-hydro_C domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of Leuk-A4-hydro_C domains in PDB

  PDB code	Main view	Title
  1gw6		STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
  1h19		STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
  1hs6		STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
  1sqm		STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE
  2r59		Leukotriene A4 hydrolase complexed with inhibitor RB3041
  2vj8		Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor
  2xpy		Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae
  2xpz		Structure of native yeast LTA4 hydrolase
  2xq0		Structure of yeast LTA4 hydrolase in complex with Bestatin
  3b7r		Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040
  3b7s		[E296Q]LTA4H in complex with RSR substrate
  3b7t		[E296Q]LTA4H in complex with Arg-Ala-Arg substrate
  3b7u		Leukotriene A4 Hydrolase Complexed with KELatorphan
  3cho		Crystal structure of leukotriene a4 hydrolase in complex with 2-amino-N-[4-(phenylmethoxy)phenyl]-acetamide
  3chp		Crystal structure of leukotriene a4 hydrolase in complex with (3S)-3-amino-4-oxo-4-[(4-phenylmethoxyphenyl)amino]butanoic acid
  3chq		Crystal structure of leukotriene a4 hydrolase in complex with N5-[4-(phenylmethoxy)phenyl]-L-glutamine
  3chr		Crystal structure of leukotriene A4 hydrolase in complex with 4-amino-N-[4-(phenylmethoxy)phenyl]-butanamide
  3chs		Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid
  3cia		Crystal structure of cold-aminopeptidase from Colwellia psychrerythraea
  3fh5		Leukotriene A4 Hydrolase complexed with inhibitor (2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine.
  3fh7		Leukotriene A4 Hydrolase complexed with inhibitor 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidin-1-yl]butanoate.
  3fh8		Leukotriene A4 Hydrolase complexed with inhibitor 1-[2-(4-benzylphenoxy)ethyl]pyrrolidine.
  3fhe		Leukotriene A4 Hydrolase complexed with inhibitor N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-alanine.
  3fts		Leukotriene A4 hydrolase in complex with resveratrol
  3ftu		Leukotriene A4 hydrolase in complex with dihydroresveratrol
  3ftv		Leukotriene A4 hydrolase in complex with fragment N-(pyridin-3-ylmethyl)aniline
  3ftw		Leukotriene A4 hydrolase in complex with fragments N-(pyridin-3-ylmethyl)aniline and acetate
  3ftx		Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin
  3fty		Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine
  3ftz		Leukotriene A4 hydrolase in complex with fragment 2-(pyridin-3-ylmethoxy)aniline
  3fu0		Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine
  3fu3		Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol
  3fu5		Leukotriene A4 hydrolase in complex with (5-thiophen-2-ylthiophen-2-yl)methylamine
  3fu6		Leukotriene A4 hydrolase in complex with fragment (4-thiophen-2-ylphenyl)methanamine
  3fud		Leukotriene A4 hydrolase in complex with N-methyl-1-(2-thiophen-2-ylphenyl)methanamine
  3fue		Leukotriene A4 hydrolase in complex with fragment 5-chloroindole and bestatin
  3fuf		Leukotriene A4 hydrolase in complex with fragment 5-fluoroindole and bestatin
  3fuh		Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin
  3fui		Leukotriene A4 hydrolase in complex with N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline
  3fuj		Leukotriene A4 hydrolase in complex with 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole
  3fuk		Leukotriene A4 hydrolase in complex with 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid
  3ful		Leukotriene A4 hydrolase in complex with pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
  3fum		Leukotriene A4 hydrolase in complex with (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol
  3fun		Leukotriene A4 hydrolase in complex with {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone
  3u9w		Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
  4dpr		Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril
  4gaa		Structure of Leukotriene A4 hydrolase from Xenopus laevis complexed with inhibitor bestatin
  4l2l		Human Leukotriene A4 Hydrolase complexed with ligand 4-(4-benzylphenyl)thiazol-2-amine
  4mkt		Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue and 4-(4-benzylphenyl)thiazol-2-amine
  4ms6		Human Leukotriene A4 Hydrolase in complex with Pro-Gly-Pro analogue
  4r7l		4R7L
  4rsy		4RSY
  4rvb		4RVB
  5aen		5AEN
  5bpp		5BPP
  5fwq		5FWQ

• Links (links to other resources describing this domain)

• PFAM	Leuk-A4-hydro_C
  INTERPRO	IPR015211

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