This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. This family is the N terminal of various melanoma associated antigens. These are tumor rejection antigens which are expressed on HLA-A1 of tumor cells and they are recognized by cytotoxic T lymphocytes (CTLs).
This domain is found N-terminal in various melanoma associated antigens from eukaryotes, and is typically between 82 and 96 amino acids in length. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs) [ (PUBMED:7642112) ].
Family alignment:
There are 2336 MAGE_N domains in 2261 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing MAGE_N domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with MAGE_N domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing MAGE_N domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Sequence analysis of the MAGE gene family encoding human tumor-rejectionantigens.
Gene. 1995; 160: 287-90
Display abstract
The MAGE multigene family, which includes the MAGE-1 and -3 genes that encodetumor-rejection antigens on HLA-A1 recognized by cytotoxic T-lymphocytes (CTL),is preferentially expressed at the mRNA level on human malignant cells, but noton normal cells. However, little is known about the MAGE-4, -41 and -6 genes. In this study, we have amplified 1040 bp (MAGE-1), 1061 bp (MAGE-3 and -6) and 1064 bp (MAGE-4 and -41) cDNA fragments, including the entire coding sequences(927-951 bp), using the reverse transcription-polymerase chain reaction (RT-PCR) method followed by nucleotide (nt) sequencing. One member had greater than 80 or 66% homology with the other members at the nt or deduced amino acid (aa) levels, respectively. Higher homology was found between MAGE-3 and -6 (98% at the ntlevel) and also between MAGE-4 and -41 (98%). The results of this investigationdemonstrated high homology, as well as the clear differences between the members of the MAGE family at the coding sequence level.
Links (links to other resources describing this domain)
