Mago binding
SMART accession number:SM01273
Description: Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions PMID:14968132.
Interpro abstract (IPR015362):

Partner of Y14 and mago (PYM, also known as WIBG) is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation [ (PUBMED:18026120) (PUBMED:19410547) ].

The N-terminal domain of PYM adopts a small globular all-beta-domain structure, with a three-stranded beta-sheet and a contiguous beta-hairpin. It binds to both Mago and Y14 [ (PUBMED:14968132) ].

Family alignment:
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There are 1405 Mago-bind domains in 1383 proteins in SMART's nrdb database.

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