Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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MltA MltA specific insert domain

SMART accession number:	SM00925
Description:	This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.
Interpro abstract (IPR005300):	Escherichia coli MltA is a membrane-bound lytic transglycosylase comprised of two domains separated by a large groove, where the peptidoglycan strand binds. Domain A is made up of an N-terminal and a C-terminal portion, which correspond to the 3D domain, named for 3 conserved aspartate residues. Domain B is inserted within the linear sequence of domain A [ (PUBMED:16139297) (PUBMED:16618494) (PUBMED:17502382) ]. MltA is a membrane-bound, murein degrading transglycosylase enzyme that plays an important role in the controlled growth of the stress-bearing sacculus of E. coli [ (PUBMED:10037771) (PUBMED:9287002) ].
GO function:	hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 6585 MltA domains in 6585 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing MltA domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with MltA domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing MltA domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: interaction
  

• Structure (3D structures containing this domain)

• 3D Structures of MltA domains in PDB

  PDB code	Main view	Title
  2ae0		Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold
  2g5d		Crystal structure of MltA from Neisseria gonorrhoeae Monoclinic form
  2g6g		Crystal structure of MltA from Neisseria gonorrhoeae
  2gae		Crystal structure of MltA from E. coli
  2pi8		Crystal structure of E. coli MltA with bound chitohexaose
  2pic		E. coli lytic transglycosylase MltA-D308A in apo-2 form
  2pjj		E. coli lytic transglycosylase MltA-D308A in apo-1 form
  2pnw		Crystal structure of membrane-bound lytic murein transglycosylase from Agrobacterium tumefaciens
  3czb		Crystal structure of putative transglycosylase from Caulobacter crescentus

• Links (links to other resources describing this domain)

• PFAM	MltA
  INTERPRO	IPR005300

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