Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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NAT_PEP Natriuretic peptide

SMART accession number:	SM00183
Description:	Atrial natriuretic peptides are vertebrate hormones important in the overall control of cardiovascular homeostasis and sodium and water balance in general.
Interpro abstract (IPR000663):	Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [ (PUBMED:1652921) (PUBMED:2536732) ]. There are different NPs that vary in length but share a common core. All are processed from a single precursor. A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP) [ (PUBMED:1828035) ]; and green mamba natriuretic peptide (DNP) [ (PUBMED:1352773) ].
GO component:	extracellular region (GO:0005576)
GO function:	hormone activity (GO:0005179)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1243 NAT_PEP domains in 1147 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing NAT_PEP domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with NAT_PEP domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing NAT_PEP domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of NAT_PEP domains in PDB

  PDB code	Main view	Title
  1anp		SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR
  1jdp		Crystal Structure of Hormone/Receptor Complex
  1q01		Lebetin peptides, a new class of potent aggregation inhibitors
  1t34		ROTATION MECHANISM FOR TRANSMEMBRANE SIGNALING BY THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR
  1yk0		structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide
  1yk1		structure of natriuretic peptide receptor-C complexed with brain natriuretic peptide
  3n56		Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human B-type natriuretic peptide (BNP)
  3n57		Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)

• Links (links to other resources describing this domain)

• PROSITE	NATRIURETIC_PEPTIDE
  INTERPRO	IPR000663

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