Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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NEAT NEAr Transporter domain

SMART accession number:	SM00725
Description:	-
Interpro abstract (IPR006635):	This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone [ (PUBMED:12823809) ]. In Staphylococcus aureus, isdH protein contains three NEAT (NEAr Transporter) domains: IsdH(N1), IsdH(N2), and IsdH(N3). These three domains have different functions, IsdH(N1) binds hemoglobin and haptoglobin, whereas IsdH(N3) captures heme that is released from hemoglobin [ (PUBMED:18984582) (PUBMED:16762363) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 5397 NEAT domains in 2292 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing NEAT domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with NEAT domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing NEAT domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of NEAT domains in PDB

  PDB code	Main view	Title
  2e7d		Crystal structure of a NEAT domain from Staphylococcus aureus
  2h3k		Solution Structure of the first NEAT domain of IsdH
  2ite		Crystal structure of the IsdA NEAT domain from Staphylococcus aureus
  2itf		Crystal structure IsdA NEAT domain from Staphylococcus aureus with heme bound
  2k78		Solution Structure of the IsdC NEAT domain bound to Zinc Protoporphyrin
  2moq		2MOQ
  2o1a		Crystal structure of iron-regulated surface determinant protein A from Staphylococcus aureus- targeted domain 47...188
  2o6p		Crystal Structure of the heme-IsdC complex
  2z6f		Crystal structure of NEAT domain from Staphylococcus aureus in complex with heme
  3ovu		Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus
  3qug		Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin
  3quh		Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Manganese(III)-porphyrin
  3qzl		Staphylococcus aureus IsdA NEAT domain K75A variant in complex with heme
  3qzm		Staphylococcus aureus IsdA NEAT domain H83A variant in complex with heme
  3qzn		Staphylococcus aureus IsdA NEAT domain Y166A variant in complex with heme
  3qzo		Staphylococcus aureus IsdA NEAT domain in complex with heme, reduced crystal
  3qzp		Staphylococcus aureus IsdA NEAT domain in complex with cobalt-protoporphyrin IX
  3rtl		Staphylococcus aureus heme-bound IsdB-N2
  3rur		Staphylococcus aureus heme-bound selenomethionine-labeled IsdB-N2
  3s48		Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus
  3sik		Crystal structure of the Bacillus anthracis hemophore IsdX1 complexed with heme
  3sz6		IsdX1, an anthrax hemophore
  3szk		Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus
  3vtm		Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin
  3vua		Apo IsdH-NEAT3 in space group P3121 at a resolution of 1.85 A
  4fc3		Crystal Structure of Human Methaemoglobin Complexed with the Second NEAT Domain of IsdH from Staphylococcus aureus
  4h8p		NEAT5 domain of IsdX2, a B. anthracis hemophore in complex with heme
  4h8q		Structure of the Q29T IsdX2-NEAT5 mutant in complex with heme
  4ij2		Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus
  4myp		4MYP
  4nla		4NLA
  4wjg		4WJG
  4xs0		4XS0
  4ymp		4YMP
  5d1q		5D1Q
  5d1x		5D1X
  5d1z		5D1Z

• Links (links to other resources describing this domain)

• INTERPRO	IPR006635

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