Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PKS_AT Acyl transferase domain in polyketide synthase (PKS) enzymes.

SMART accession number:	SM00827
Description:	-
Interpro abstract (IPR014043):	Enzymes like bacterial malonyl CoA-acly carrier protein transacylase ( EC 2.3.1.39 ) and eukaryotic fatty acid synthase ( EC 2.3.1.85 ) that are involved in fatty acid biosynthesis belong to this group. Also included are the polyketide synthases 6-methylsalicylic acid synthase ( EC 2.3.1 ), a multifunctional enzyme that involved in the biosynthesis of patulin and conidial green pigment synthase ( EC 2.3.1 ).
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 39850 PKS_AT domains in 31164 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PKS_AT domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PKS_AT domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PKS_AT domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 9.55 map00632 Benzoate degradation via CoA ligation 8.99 map01053 Biosynthesis of siderophore group nonribosomal peptides 8.43 map00350 Tyrosine metabolism 8.43 map00564 Glycerophospholipid metabolism 8.43 map00960 Alkaloid biosynthesis II 8.43 map00903 Limonene and pinene degradation 8.43 map00310 Lysine degradation 8.43 map00340 Histidine metabolism 8.43 map00360 Phenylalanine metabolism 8.43 map00624 1- and 2-Methylnaphthalene degradation 8.43 map00642 Ethylbenzene degradation 2.25 map00061 Fatty acid biosynthesis 1.12 map00562 Inositol phosphate metabolism 0.56 map00860 Porphyrin and chlorophyll metabolism 0.56 map04920 Adipocytokine signaling pathway 0.56 map03320 PPAR signaling pathway 0.56 map00071 Fatty acid metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_AT domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_AT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_AT domains in PDB

  PDB code	Main view	Title
  2hg4		Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.
  2qo3		Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase
  3tzw		Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the orthorhombic apoform at 2.6 A
  3tzx		Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in tetragonal apo form at 2.3 A
  3tzy		Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the palmitoylated form at 2.2 A
  3tzz		Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the carboxypalmitoylated form at 2.5 A
  4mz0		Structure of a ketosynthase-acyltransferase di-domain from module CurL of the curacin A polyketide synthase
  4qbu		4QBU
  4rl1		4RL1
  5bp1		5BP1

• Links (links to other resources describing this domain)

• INTERPRO	IPR014043

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