Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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PKS_DH

SMART accession number:	SM00826
Description:	-
Interpro abstract (IPR020807):	This entry represents the dehydratase domain found in polyketide synthases.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 24240 PKS_DH domains in 19872 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing PKS_DH domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PKS_DH domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing PKS_DH domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 11.43 map00632 Benzoate degradation via CoA ligation 9.52 map00350 Tyrosine metabolism 9.52 map00564 Glycerophospholipid metabolism 9.52 map00903 Limonene and pinene degradation 9.52 map00960 Alkaloid biosynthesis II 9.52 map00310 Lysine degradation 9.52 map00624 1- and 2-Methylnaphthalene degradation 9.52 map00360 Phenylalanine metabolism 9.52 map00340 Histidine metabolism 9.52 map00642 Ethylbenzene degradation 1.90 map00562 Inositol phosphate metabolism 0.95 map00061 Fatty acid biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_DH domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_DH domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_DH domains in PDB

  PDB code	Main view	Title
  3el6		Crystal Structure of the Erythromycin Dehydratase
  3kg6		Dehydratase domain from CurF module of Curacin polyketide synthase
  3kg7		Dehydratase domain from CurH module of Curacin polyketide synthase
  3kg8		Dehydratase domain from CurJ module of Curacin polyketide synthase
  3kg9		Dehydratase domain from CurK module of Curacin polyketide synthase
  4ln9		Crystal structure of the dehydratase domain from the terminal module of the rifamycin polyketide synthase
  4ooc		4OOC
  4p7p		4P7P
  5bp2		5BP2
  5bp3		5BP3
  5bp4		5BP4
  5cf7		5CF7

• Links (links to other resources describing this domain)

• INTERPRO	IPR020807

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