SMART: Pro-kuma_activ domain annotation

Pro-kuma_activ Pro-kumamolisin, activation domain

SMART accession number:	SM00944
Description:	This domain is found at the N-terminus of peptidases belonging to MEROPS peptidase family S53 (sedolisin, clan SB). The domain adopts a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptidase (PUBMED:15242607).
Interpro abstract (IPR015366):	This domain is found at the N terminus of peptidases belonging to MEROPS peptidase family S53 (sedolisin, clan SB). The domain adopts a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptidase [ (PUBMED:15242607) ].
GO function:	serine-type peptidase activity (GO:0008236)
Family alignment:	View or

There are 6403 Pro-kuma_activ domains in 6400 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing Pro-kuma_activ domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Pro-kuma_activ domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing Pro-kuma_activ domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Cellular role: metabolism
Structure (3D structures containing this domain)

PDB code	Main view	Title
1t1e		High Resolution Crystal Structure of the Intact Pro-Kumamolisin, a Sedolisin Type Proteinase (previously called Kumamolysin or KSCP)
3edy		Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1
3ee6		Crystal Structure Analysis of Tripeptidyl peptidase -I

Pro-kuma_activ