Ras-binding domain of Byr2
SMART accession number:SM01304
Description: This domain is the binding/interacting region of several protein kinases, such as the Schizosaccharomyces pombe Byr2. Byr2 is a Ser/Thr-specific protein kinase acting as mediator of signals for sexual differentiation in S. pombe by initiating a MAPK module, which is a highly conserved element in eukaryotes. Byr2 is activated by interacting with Ras, which then translocates the molecule to the plasma membrane. Ras proteins are key elements in intracellular signaling and are involved in a variety of vital processes such as DNA transcription, growth control, and differentiation. They function like molecular switches cycling between GTP-bound on and GDP-bound off states PMID:11709168.
Interpro abstract (IPR029458):

This entry represents the Ras binding/interacting domain of the Byr2 protein from Schizosaccharomyces pombe. The Ras binding domain (RBD) of Byr2 is necessary and sufficient for the protein to be translocated by Ras to the plasma membrane [ (PUBMED:11709168) ]. This domain can also be found in Ste11 protein from Saccharomyces cerevisiae.

Byr2 is mitogen-activated protein/ERK kinase kinase (MEKK) that responds to pheromone signalling and controls mating through a mitogen-activated protein kinase (MAPK) pathway [ (PUBMED:16754851) ]. The small GTP binding protein Ras binds and activates Byr2 [ (PUBMED:11709168) ].

Ste11 is a mitogen activated protein kinase kinase kinase (MAPKKK) involved in the MAPK pathways governing mating, osmosensing, and filamentous growth [ (PUBMED:15567849) ].

Family alignment:
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There are 375 Ras_bdg_2 domains in 375 proteins in SMART's nrdb database.

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