The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.
Family alignment:
There are 14201 SOCS_box domains in 14182 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing SOCS_box domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with SOCS_box domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing SOCS_box domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
The SOCS box: a tale of destruction and degradation.
Trends Biochem Sci. 2002; 27: 235-41
Display abstract
Although initially identified in the suppressor of cytokine signaling(SOCS) family of proteins, the C-terminal SOCS box has now been identifiedin more than 40 proteins in nine different families. Growing evidencesuggests that the SOCS box, similar to the F-box, acts as a bridge betweenspecific substrate-binding domains and the more generic proteins thatcomprise a large family of E3 ubiquitin protein ligases. In this way, SOCSproteins regulate protein turnover by targeting proteins forpolyubiquitination and, therefore, for proteasome-mediated degradation.
