SpoVT / AbrB like domain
SMART accession number:SM00966
Description: This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation (PUBMED:2504584). AbrB is thought to interact directly with the transcription initiation regions of genes under its control (PUBMED:8755877). AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins (PUBMED:1908787). The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator (PUBMED:8755877). DNA-binding activity in this AbrB homologue requires hexamerisation (PUBMED:10978510). Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins (PUBMED:2152898).
Interpro abstract (IPR007159):

The SpoVT-AbrB domain is a DNA-binding domain found in a large protein superfamily [ (PUBMED:16223496) (PUBMED:15939023) ], which includes:

  • Bacterial antibiotic resistance protein B (AbrB), a transition-state regulator.
  • Bacterial SpoVT, a late sporulation factor that modulates forespore-specific sigma G-dependent transcription.
  • Bacterial PrlF, an antitoxin component of a toxin-antitoxin (TA) module.
  • Bacterial transcription factors (antitoxins) of plasmid maintenance systems (VapB, MvpT, VppA,VagC, PemI, MazE, ChpS).
  • Bacterial transcriptional regulator MraZ, involved in the expression of the division and cell wall (dcw) cluster. It contains two copies of the SpoVT-AbrB domain.
  • Bacterial endoribonuclease SymE.
  • Sulfolobus solfataricus repressor-like proteins SSo7c3 and SSo7c4.

The SpoVT-AbrB domain contains four beta strands and one alpha helix and can be described as a pair of beta hairpins linked by the alpha helix [ (PUBMED:16223496) (PUBMED:15939023) ].

GO function:DNA binding (GO:0003677)
Family alignment:
View or

There are 22580 SpoVT_AbrB domains in 22433 proteins in SMART's nrdb database.

Click on the following links for more information.