Thymosin beta actin-binding motif.
SMART accession number:SM00152
Description: -
Interpro abstract (IPR001152):

This entry represents beta-thymosin family. Its members include thymosin beta-4, -10, -15 from humans and their homologues (such as thymosin beta 11/12) from fish.

Thymosin beta-4 (Tbeta) is a small protein that sequesters actin monomers to help maintain the high concentrations of unpolymerised actin in higher eukaryotic cells. Its structure has been resolved [ (PUBMED:25313062) ]. It is a multiple function protein that plays important roles in cellular processes such as wound healing, embryonic organ development and the pathogeneses of disease [ (PUBMED:24993983) (PUBMED:24732964) ]. It plays a role in anti-apoptotic response to an external stress [ (PUBMED:15037574) ], paclitaxel-resistance via ROS production [ (PUBMED:18306930) (PUBMED:20637781) ] and HIF-1alpha stabilisation via Erk activation [ (PUBMED:18272284) ]. It also regulates cancer cell migration through various signalling pathways, and hence plays a role in malignant progression and invasion in colon adenocarcinoma [ (PUBMED:22328534) (PUBMED:12761500) ].

Thymosin beta-15 has been reported to be up-regulated in breast, brain, lung and head and neck cancer [ (PUBMED:17567946) ]. The expression of thymosin beta-10 is also associated with many cancers [ (PUBMED:24053380) ].

GO process:actin filament organization (GO:0007015)
GO function:actin monomer binding (GO:0003785)
Family alignment:
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There are 2289 THY domains in 910 proteins in SMART's nrdb database.

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