Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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TRCF

SMART accession number:	SM00982
Description:	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.
Interpro abstract (IPR005118):	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript. The C-terminal region of TRCF have been shown to be necessary for RNAP displacement [ (PUBMED:7876261) (PUBMED:14602898) ].
GO process:	DNA repair (GO:0006281)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 21131 TRCF domains in 21131 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing TRCF domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with TRCF domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing TRCF domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: chromatin
  

• Structure (3D structures containing this domain)

• 3D Structures of TRCF domains in PDB

  PDB code	Main view	Title
  2eyq		Crystal structure of Escherichia coli transcription-repair coupling factor
  2qsr		Crystal structure of C-terminal domain of transcription-repair coupling factor

• Links (links to other resources describing this domain)

• PFAM	TRCF
  INTERPRO	IPR005118

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