This domain is distantly similar to MD-2-related lipid-recognition domain ( IPR003172 ) and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding. Proteins containing this domain include flavin carrier protein 1/2 from budding yeasts [ (PUBMED:16717099) ] and TRP-like ion channel pkd2 from fission yeasts [ (PUBMED:15537393) ].
Family alignment:
There are 1869 TRP_N domains in 1867 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing TRP_N domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with TRP_N domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing TRP_N domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
A microbial TRP-like polycystic-kidney-disease-related ion channel gene.
Biochem J. 2005; 387: 211-9
Display abstract
Ion channel genes have been discovered in many microbial organisms. We haveinvestigated a microbial TRP (transient receptor potential) ion channel genewhich has most similarity to polycystic-kidney-disease-related ion channel genes.We have shown that this gene (pkd2) is essential for cellular viability, and isinvolved in cell growth and cell wall synthesis. Expression of this geneincreases following damage to the cell wall. This fission yeast pkd2 gene,orthologues of which are found in all eukaryotic cells, appears to be a keysignalling component in the regulation of cell shape and cell wall synthesis inyeast through an interaction with a Rho1-GTPase. A model for the mode of actionof this Schizosaccharomyces pombe protein in a Ca2+ signalling pathway ishypothesized.
Links (links to other resources describing this domain)
