Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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UME Domain in UVSB PI-3 kinase, MEI-41 and ESR-1

SMART accession number:	SM00802
Description:	Characteristic domain in UVSP PI-3 kinase, MEI-41 and ESR-1. Found in nucleolar proteins. Associated with FAT, FATC, PI3_PI4_kinase modules.
Interpro abstract (IPR012993):	This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [ (PUBMED:15112237) ].
GO function:	protein serine/threonine kinase activity (GO:0004674)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1292 UME domains in 1289 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing UME domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with UME domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing UME domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Staub E, Fiziev P, Rosenthal A, Hinzmann B
  • Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.
  • Bioessays. 2004; 26: 567-81
  • Display abstract

  • Recently, the first investigation of nucleoli using mass spectrometry led to the identification of 271 proteins. This represents a rich resource for a comprehensive investigation of nucleolus evolution. We applied a protocol for the identification of known and novel conserved protein domains of the nucleolus, resulting in the identification of 115 known and 91 novel domain profiles. The phyletic distribution of nucleolar protein domains in a collection of complete proteomes of selected organisms from all domains of life confirms the archaebacterial origin of the core machinery for ribosome maturation and assembly, but also reveals substantial eubacterial and eukaryotic contributions to nucleolus evolution. We predict that, in different phases of nucleolus evolution, protein domains with different biochemical functions were recruited to the nucleolus. We suggest a model for the late and continuous evolution of the nucleolus in early eukaryotes and argue against an endosymbiotic origin of the nucleolus and the nucleus. Supplementary material for this article can be found on the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 41.18 map04115 p53 signaling pathway 41.18 map04110 Cell cycle 17.65 map04111 Cell cycle - yeast This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with UME domain which could be assigned to a KEGG orthologous group, and not all proteins containing UME domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• PFAM	UME
  INTERPRO	IPR012993

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