Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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WR1 Worm-specific repeat type 1

SMART accession number:	SM00289
Description:	Worm-specific repeat type 1. Cysteine-rich domain apparently unique (so far) to C. elegans. Often appears with KU domains. About 3 dozen worm proteins contain this domain.
Interpro abstract (IPR006150):	This repeat, originally named as Worm-specific repeat type 1, is found in several Caenorhabditis elegans proteins, as well as some other eukaryotes. The region contains several conserved cysteines that probably form disulphide bridges and is often found associated with kunitz domains IPR002223 that may function as serine peptidase inhibitors; these belong to MEROPS peptidase inhibitor family I2.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 14923 WR1 domains in 4256 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing WR1 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with WR1 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing WR1 domain in the selected taxonomic class.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 50.00 map00562 Inositol phosphate metabolism 50.00 map00632 Benzoate degradation via CoA ligation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with WR1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing WR1 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Links (links to other resources describing this domain)

• INTERPRO	IPR006150

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