TDU

Short repeats in human TONDU, fly vestigial and other proteins.
TDU
SMART accession number:SM00711
Description: Unknown function.
Interpro abstract (IPR006627):

The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. The human protein, TONDU, contains a short domain homologous to the domain of Vg required for interaction with Sd. TONDU specifically interacts with a domain conserved in all the mammalian TEF factors [(PUBMED:10518497)].

Family alignment:
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There are 776 TDU domains in 538 proteins in SMART's nrdb database.

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