AFOR_N

Aldehyde ferredoxin oxidoreductase, N-terminal domain
AFOR_N
SMART accession number:SM00790
Description: Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family (PUBMED:9242907) contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion of aldehydes to carboxylates (PUBMED:8672295). This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde-3-phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea (PUBMED:9242907); carboxylic acid reductase found in clostridia (PUBMED:2550230); and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum (PUBMED:8026480). GAPOR may be involved in glycolysis (PUBMED:7721730), but the functions of the other proteins are not yet clear. AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid oxidoreductases (PUBMED:9275170).
Interpro abstract (IPR013983):

Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family [(PUBMED:9242907)] contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion of aldehydes to carboxylates [(PUBMED:8672295)]. This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde-3-phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea [(PUBMED:9242907)]; carboxylic acid reductase found in clostridia [(PUBMED:2550230)]; and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum [(PUBMED:8026480)]. GAPOR may be involved in glycolysis [(PUBMED:7721730)], but the functions of the other proteins are not yet clear. AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid oxidoreductases [(PUBMED:9275170)].

This entry represents the N-terminal domain of these enzymes. This domain has been shown to interact with the tungsten cofactor [(PUBMED:7878465)].

GO process:oxidation-reduction process (GO:0055114)
GO function:iron-sulfur cluster binding (GO:0051536), oxidoreductase activity (GO:0016491), oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor (GO:0016625)
Family alignment:
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There are 1455 AFOR_N domains in 1455 proteins in SMART's nrdb database.

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