domain in transcription factors and synapse-associated proteins
SMART accession number:SM00751
Interpro abstract (IPR005607):

The BSD domain is an about 60-residue long domain named after the BTF2-like transcription factors, Synapse-associated proteins and DOS2-like proteins in which it is found. Additionally, it is also found in several hypothetical proteins. The BSD domain occurs in one or two copies in a variety of species ranging from primal protozoan to human. It can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. The function of the BSD domain is unknown [ (PUBMED:11943536) ].

Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues - less common amino acids that are invariant in all the BSD domains identified and that are the most striking sequence features of the domain [ (PUBMED:11943536) ].

Some proteins known to contain one or two BSD domains are listed below:
  • Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1).
  • Yeast RNA polymerase II transcription factor B 73kDa subunit (TFB1), the homologue of BTF2.
  • Yeast DOS2 protein. It is involved in single-copy DNA replication and ubiquitination.
  • Drosophila synapse-associated protein SAP47.
  • Mammalian SYAP1.
  • Various Arabidopsis thaliana (Mouse-ear cress) hypothetical proteins.
Family alignment:
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There are 5814 BSD domains in 4467 proteins in SMART's nrdb database.

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