The BLUF domain has been shown to bind FAD in the AppA protein (Q53119). AppA is involved in the repression of photosynthesis genes in response to blue-light.
The BLUF domain (named for sensors of Blue-Light Using FAD) is an FAD-binding protein domain. BLUF domains are present in various proteins, primarily from bacteria. For example a BLUF domain is found at the N terminus of the AppA protein from Rhodobacter sphaeroides [ (PUBMED:16323221) ]. BLUF domains are involved in sensing blue-light (and possibly redox) using FAD, and are similar to the flavin-binding PAS domains and cryptochromes. Their predicted secondary structure reveals that the BLUF domains have a novel FAD-binding fold [ (PUBMED:12368079) ].
BLUF: a novel FAD-binding domain involved in sensory transduction inmicroorganisms.
Trends Biochem Sci. 2002; 27: 497-500
Display abstract
A novel FAD-binding domain, BLUF, exemplified by the N-terminus of theAppA protein from Rhodobacter sphaeroides, is present in various proteins,primarily from Bacteria. The BLUF domain is involved in sensing blue-light(and possibly redox) using FAD and is similar to the flavin-binding PASdomains and cryptochromes. The predicted secondary structure reveals thatthe BLUF domain is a novel FAD-binding fold.
