Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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POLAc DNA polymerase A domain

SMART accession number:	SM00482
Description:	-
Interpro abstract (IPR001098):	Synonym(s): DNA nucleotidyltransferase (DNA-directed) DNA-directed DNA polymerases( EC 2.7.7.7 ) are the key enzymes catalysing the accurate replication of DNA. They require either a small RNA molecule or a protein as a primer for the de novo synthesis of a DNA chain. A number of polymerases belong to this family [ (PUBMED:2196557) (PUBMED:1870963) (PUBMED:8451181) ].
GO process:	DNA replication (GO:0006260)
GO function:	DNA binding (GO:0003677), DNA-directed DNA polymerase activity (GO:0003887)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 28198 POLAc domains in 28190 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing POLAc domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with POLAc domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing POLAc domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: replication
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Braithwaite DK, Ito J
  • Compilation, alignment, and phylogenetic relationships of DNA polymerases.
  • Nucleic Acids Res. 1993; 21: 787-802

  • Ollis DL, Brick P, Hamlin R, Xuong NG, Steitz TA
  • Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP.
  • Nature. 1985; 313: 762-6
  • Display abstract

  • The 3.3-A resolution crystal structure of the large proteolytic fragment of Escherichia coli DNA polymerase I complexed with deoxythymidine monophosphate consists of two domains, the smaller of which binds zinc-deoxythymidine monophosphate. The most striking feature of the larger domain is a deep crevice of the appropriate size and shape for binding double-stranded B-DNA. A flexible subdomain may allow the enzyme to surround completely the DNA substrate, thereby allowing processive nucleotide polymerization without enzyme dissociation.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 33.33 map00240 Pyrimidine metabolism 33.33 map03030 DNA replication 33.33 map00230 Purine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with POLAc domain which could be assigned to a KEGG orthologous group, and not all proteins containing POLAc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of POLAc domains in PDB

  PDB code	Main view	Title
  1bgx		TAQ POLYMERASE IN COMPLEX WITH TP7, AN INHIBITORY FAB
  1d8y		CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA
  1d9d		CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'
  1d9f		CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA TETRAMER CARRYING 2'-O-(3-AMINOPROPYL)-RNA MODIFICATION 5'-D(TT)-AP(U)-D(T)-3'
  1dpi		STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP
  1jxe		STOFFEL FRAGMENT OF TAQ DNA POLYMERASE I
  1kfd		CRYSTAL STRUCTURES OF THE KLENOW FRAGMENT OF DNA POLYMERASE I COMPLEXED WITH DEOXYNUCLEOSIDE TRIPHOSPHATE AND PYROPHOSPHATE
  1kfs		DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
  1kln		DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
  1krp		DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
  1ksp		DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
  1ktq		DNA POLYMERASE
  1l3s		Crystal Structure of Bacillus DNA Polymerase I Fragment complexed to 9 base pairs of duplex DNA.
  1l3t		Crystal Structure of Bacillus DNA Polymerase I Fragment product complex with 10 base pairs of duplex DNA following addition of a single dTTP residue
  1l3u		Crystal Structure of Bacillus DNA Polymerase I Fragment product complex with 11 base pairs of duplex DNA following addition of a dTTP and a dATP residue.
  1l3v		Crystal Structure of Bacillus DNA Polymerase I Fragment product complex with 15 base pairs of duplex DNA following addition of dTTP, dATP, dCTP, and dGTP residues.
  1l5u		Crystal Structure of Bacillus DNA Polymerase I Fragment product complex with 12 base pairs of duplex DNA following addition of a dTTP, a dATP, and a dCTP residue.
  1lv5		Crystal Structure of the Closed Conformation of Bacillus DNA Polymerase I Fragment Bound to DNA and dCTP
  1njw		GUANINE-THYMINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1njx		THYMINE-GUANINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1njy		THYMINE-THYMINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1njz		CYTOSINE-THYMINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk0		ADENINE-GUANINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk4		GUANINE-GUANINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk5		ADENINE-ADENINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk6		CYTOSINE-CYTOSINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk7		GUANINE-ADENINE MISMATCH AT THE POLYMERASE ACTIVE SITE
  1nk8		A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER A SINGLE ROUND OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP.
  1nk9		A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER TWO ROUNDS OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP AND DGTP.
  1nkb		A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER THREE ROUNDS OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP, DGTP, AND DTTP.
  1nkc		A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A GUANINE-THYMINE MISMATCH AFTER FIVE ROUNDS OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP, DGTP, DTTP, AND DATP.
  1nke		A BACILLUS DNA POLYMERASE I PRODUCT COMPLEX BOUND TO A CYTOSINE-THYMINE MISMATCH AFTER A SINGLE ROUND OF PRIMER EXTENSION, FOLLOWING INCORPORATION OF DCTP.
  1qsl		KLENOW FRAGMENT COMPLEXED WITH SINGLE-STRANDED SUBSTRATE AND EUROPIUM (III) ION
  1qss		DDGTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
  1qsy		DDATP-Trapped closed ternary complex of the large fragment of DNA Polymerase I from thermus aquaticus
  1qtm		DDTTP-TRAPPED CLOSED TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
  1skr		T7 DNA Polymerase Complexed To DNA Primer/Template and ddATP
  1sks		Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template
  1skw		Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template
  1sl0		Ternary 3' complex of T7 DNA polymerase with a DNA primer/template containing a disordered cis-syn thymine dimer on the template and an incoming nucleotide
  1sl1		Binary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template
  1sl2		Ternary 5' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template and an incoming nucleotide
  1t7p		T7 DNA POLYMERASE COMPLEXED TO DNA PRIMER/TEMPLATE,A NUCLEOSIDE TRIPHOSPHATE, AND ITS PROCESSIVITY FACTOR THIOREDOXIN
  1t8e		T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site.
  1taq		STRUCTURE OF TAQ DNA POLYMERASE
  1tau		TAQ POLYMERASE (E.C.2.7.7.7)/DNA/B-OCTYLGLUCOSIDE COMPLEX
  1tk0		T7 DNA polymerase ternary complex with 8 oxo guanosine and ddCTP at the insertion site
  1tk5		T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand
  1tk8		T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site
  1tkd		T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site
  1u45		8oxoguanine at the pre-insertion site of the polymerase active site
  1u47		cytosine-8-Oxoguanine base pair at the polymerase active site
  1u48		Extension of a cytosine-8-oxoguanine base pair
  1u49		Adenine-8oxoguanine mismatch at the polymerase active site
  1u4b		Extension of an adenine-8oxoguanine mismatch
  1ua0		Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase
  1ua1		Structure of aminofluorene adduct paired opposite cytosine at the polymerase active site.
  1x9m		T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA
  1x9s		T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-CTP as the incoming nucleotide.
  1x9w		T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-ATP as the incoming nucleotide.
  1xc9		Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication
  1xwl		BACILLUS STEAROTHERMOPHILUS (NEWLY IDENTIFIED STRAIN AS YET UNNAMED) DNA POLYMERASE FRAGMENT
  1zyq		T7 DNA polymerase in complex with 8oG and incoming ddATP
  2ajq		Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing
  2bdp		CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 9 BASE PAIRS OF DUPLEX DNA
  2hhq		O6-methyl-guanine:T pair in the polymerase-10 basepair position
  2hhs		O6-methyl:C pair in the polymerase-10 basepair position
  2hht		C:O6-methyl-guanine pair in the polymerase-2 basepair position
  2hhu		C:O6-methyl-guanine in the polymerase postinsertion site (-1 basepair position)
  2hhv		T:O6-methyl-guanine in the polymerase-2 basepair position
  2hhw		ddTTP:O6-methyl-guanine pair in the polymerase active site, in the closed conformation
  2hhx		O6-methyl-guanine in the polymerase template preinsertion site
  2hvh		ddCTP:O6MeG pair in the polymerase active site (0 position)
  2hvi		ddCTP:G pair in the polymerase active site (0 position)
  2hw3		T:O6-methyl-guanine pair in the polymerase postinsertion site (-1 basepair position)
  2kfn		KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND MANGANESE
  2kfz		KLENOW FRAGMENT WITH BRIDGING-SULFUR SUBSTRATE AND ZINC ONLY
  2ktq		OPEN TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
  2kzm		KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC AND MANGANESE
  2kzz		KLENOW FRAGMENT WITH NORMAL SUBSTRATE AND ZINC ONLY
  2xo7		Crystal structure of a dA:O-allylhydroxylamine-dC basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus
  2xy5		Crystal structure of an artificial salen-copper basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus
  2xy6		Crystal structure of a salicylic aldehyde basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus
  2xy7		Crystal structure of a salicylic aldehyde base in the pre-insertion site of fragment DNA polymerase I from Bacillus stearothermophilus
  2y1i		Crystal structure of a S-diastereomer analogue of the spore photoproduct in complex with fragment DNA polymerase I from Bacillus stearothermophilus
  2y1j		Crystal structure of a R-diastereomer analogue of the spore photoproduct in complex with fragment DNA polymerase I from Bacillus stearothermophilus
  3bdp		DNA POLYMERASE I/DNA COMPLEX
  3eyz		Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA (open form)
  3ez5		Cocrystal structure of Bacillus fragment DNA polymerase I with duplex DNA , dCTP, and zinc (closed form).
  3hp6		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus F710Y mutant bound to G:T mismatch
  3hpo		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus Y714S mutant bound to G:T mismatch
  3ht3		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus V713P mutant bound to G:dCTP
  3ikm		Crystal structure of human mitochondrial DNA polymerase holoenzyme
  3ktq		CRYSTAL STRUCTURE OF AN ACTIVE TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
  3lwl		Structure of Klenow fragment of Taq polymerase in complex with an abasic site
  3lwm		Structure of the large fragment of thermus aquaticus DNA polymerase I in complex with a blunt-ended DNA and ddATP
  3m8r		Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed ternary complex with trapped 4'-ethylated dTTP
  3m8s		Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed ternary complex with trapped 4'-methylated dTTP
  3ojs		Snapshots of the large fragment of DNA polymerase I from Thermus Aquaticus processing C5 modified thymidines
  3oju		Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing c5 modified thymidies
  3po4		Structure of a mutant of the large fragment of DNA polymerase I from Thermus aquaticus in complex with a blunt-ended DNA and ddATP
  3po5		Structure of a mutant of the large fragment of DNA polymerase I from Thermus Auqaticus in complex with an abasic site and ddATP
  3pv8		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddTTP-dA in Closed Conformation
  3px0		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and dCTP-dA Mismatch (tautomer) in Closed Conformation
  3px4		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (wobble) in Ajar Conformation
  3px6		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddCTP-dA Mismatch (tautomer) in Closed Conformation
  3py8		Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a closed ternary complex with DNA and ddCTP
  3rr7		Binary Structure of the large fragment of Taq DNA polymerase bound to an abasic site
  3rr8		Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP
  3rrg		Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP
  3rrh		Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddTTP
  3rtv		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed ternary complex with natural primer/template DNA
  3sv3		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed ternary complex with the artificial base pair dNaM-d5SICSTP
  3sv4		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with dT as templating nucleobase
  3syz		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with dNaM as templating nucleobase
  3sz2		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with dG as templating nucleobase
  3t3f		Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and dNITP
  3tan		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-1) Position
  3tap		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-3) Position
  3taq		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-4) Position
  3tar		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to Duplex DNA with Cytosine-Adenine Mismatch at (n-6) Position
  3thv		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddATP-dT in Closed Conformation
  3ti0		Crystal Structure of Bacillus DNA Polymerase I Large Fragment Bound to DNA and ddGTP-dC in Closed Conformation
  4b9l		Structure of the high fidelity DNA polymerase I with the oxidative formamidopyrimidine-dA DNA lesion in the pre-insertion site.
  4b9m		Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dA DNA lesion -thymine basepair in the post- insertion site.
  4b9n		Structure of the high fidelity DNA polymerase I correctly bypassing the oxidative formamidopyrimidine-dA DNA lesion.
  4b9s		Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion outside of the pre-insertion site.
  4b9t		Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dC basepair in the post-insertion site.
  4b9u		Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site.
  4b9v		Structure of the high fidelity DNA polymerase I with extending from an oxidative formamidopyrimidine-dG DNA lesion -dA basepair.
  4bdp		CRYSTAL STRUCTURE OF BACILLUS DNA POLYMERASE I FRAGMENT COMPLEXED TO 11 BASE PAIRS OF DUPLEX DNA AFTER ADDITION OF TWO DATP RESIDUES
  4bwj		KlenTaq mutant in complex with DNA and ddCTP
  4bwm		KlenTaq mutant in complex with a RNA/DNA hybrid
  4c8k		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a partially closed complex with the artificial base pair d5SICS-dNaMTP
  4c8l		Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the artificial base pair dNaM-d5SICS at the postinsertion site (sequence context 1)
  4c8m		Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the aritificial base pair d5SICS-dNaM at the postinsertion site (sequence context 2)
  4c8n		Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the aritificial base pair dNaM-d5SICS at the postinsertion site (sequence context 3)
  4c8o		Binary complex of the large fragment of DNA polymerase I from Thermus Aquaticus with the aritificial base pair dNaM-d5SICS at the postinsertion site (sequence context 2)
  4cch		Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with d5SICS as templating nucleotide
  4df4		Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 7-(N-(10-hydroxydecanoyl)-aminopentinyl)-7-deaza-2 -dATP
  4df8		Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with aminopentinyl-7-deaza-2-dATP
  4dfj		Crystal structure of the large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 5-(aminopentinyl)-dTTP
  4dfk		large fragment of DNA Polymerase I from Thermus aquaticus in a closed ternary complex with 5-(N-(10-hydroxydecanoyl)-aminopentinyl)-2-dUTP
  4dfm		Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in ternary complex with 5-(aminopentinyl)-2-dCTP
  4dfp		Crystal structure of the large fragment of DNA Polymerase I from Thermus aqauticus in a ternary complex with 7-(aminopentinyl)-7-deaza-dGTP
  4dle		Ternary Structure of the large Fragment of Taq DNA Polymerase: 4-Fluoroproline Variant
  4dlg		Ternary Structure of the large Fragment of Taq DNA polymerase
  4dqi		Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and dCTP (paired with dG of template)
  4dqp		Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and ddCTP (paired with dG of template)
  4dqq		Ternary complex of Bacillus DNA Polymerase I Large Fragment E658A, DNA duplex, and rCTP (paired with dG of template) in presence of Mg2+
  4dqr		Ternary complex of Bacillus DNA Polymerase I Large Fragment E658A, DNA duplex, and rCTP (paired with dG of template) in presence of Mn2+
  4dqs		Binary complex of Bacillus DNA Polymerase I Large Fragment and duplex DNA with rC in primer terminus paired with dG of template
  4ds4		Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and rCTP in presence of Mn2+
  4ds5		Ternary complex of Bacillus DNA Polymerase I Large Fragment, DNA duplex, and rCTP in presence of Mg2+
  4dse		Ternary complex of Bacillus DNA Polymerase I Large Fragment F710Y, DNA duplex, and rCTP (paired with dG of template) in presence of Mg2+
  4dsf		Ternary complex of Bacillus DNA Polymerase I Large Fragment F710Y, DNA duplex, and rCTP (paired with dG of template) in presence of Mn2+
  4dsi		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, Se-dGTP and Calcium
  4dsj		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, dGTP and Calcium
  4dsk		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, PPi and Calcium
  4dsl		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA and Calcium
  4dwi		Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with self complementary DNA, Se-dGTP and Calcium
  4e0d		Binary complex of Bacillus DNA Polymerase I Large Fragment E658A and duplex DNA
  4elt		Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines
  4elu		Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines
  4elv		Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines
  4ez6		Bacillus DNA Polymerase I Large Fragment Complex 1
  4ez9		Bacillus DNA Polymerase I Large Fragment Complex 2
  4f2r		DNA Polymerase I Large Fragment complex 3
  4f2s		DNA Polymerase I Large Fragment complex 4
  4f3o		DNA Polymerase I Large Fragment Complex 5
  4f4k		DNA Polymerase I Large Fragment Complex 6
  4f8r		Bacillus DNA Polymerase I Large Fragment complex 7
  4ktq		BINARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM T. AQUATICUS BOUND TO A PRIMER/TEMPLATE DNA
  4n56		4N56
  4n5s		4N5S
  4o0i		4O0I
  4uqg		4UQG
  4x0p		4X0P
  4x0q		4X0Q
  4xiu		4XIU
  4xvi		4XVI
  4xvk		4XVK
  4xvl		4XVL
  4xvm		4XVM
  4yfu		4YFU
  4ztu		4ZTU
  4ztz		4ZTZ
  5c51		5C51
  5c52		5C52
  5c53		5C53
  5dkt		5DKT
  5dku		5DKU
  5ktq		LARGE FRAGMENT OF TAQ DNA POLYMERASE BOUND TO DCTP

• Links (links to other resources describing this domain)

• PROSITE	DNA_POLYMERASE_A
  INTERPRO	IPR001098
  PFAM	DNA_pol_A

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