DUF862

PPPDE putative peptidase domain
DUF862
SMART accession number:SM01179
Description: The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p) (PUBMED:15483401).
Family alignment:
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There are 1295 DUF862 domains in 1256 proteins in SMART's nrdb database.

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