You may use either a Uniprot/Ensembl sequence identifier (ID) / accession number (ACC) or the protein sequence itself to request the SMART service.

Sequence ID or ACC

Examples: TEC_HUMAN, C1S_HUMAN

Sequence

HMMER searches of the SMART database occur by default. You may also find:

Outlier homologues and homologues of known structure
PFAM domains
signal peptides
internal repeats
intrinsic protein disorder

If you have multiple sequences to analyze, try batch access to SMART database.

You can search for proteins with combinations of specific domains in different species or taxonomic ranges. You can input the domains directly into "Domain selection" box, or use "GO terms query" to get a list of domains. See What's New for more info.

Domain selection

Example: TyrKc AND SH3 AND NOT SH2

GO terms query

Example: membrane AND signal transduction

Taxonomic selection

Select a taxonomic range via the selection box or type it into the text box below:

All Homo sapiens Mus musculus Drosophila melanogaster Caenorhabditis elegans Arabidopsis thaliana Saccharomyces cerevisiae Schizosaccharomyces pombe Chordata Arthropoda Nematoda Metazoa Fungi Viridiplantae Eukaryota Archaea Bacteria
Examples: Dictyostelium discoideum, Porifera

You can try an Advanced Query if you're familiar with SQL.